DermatologistsBlog.com eInterview with:
Jennifer A. Stein, MD, PhD
Department of Dermatology, New York University School of Medicine
240 E 38 St, 11th Floor, New York, NY 10016.
DermatologistsBlog.com: What are the main findings of the study?
Dr. Stein: We describe a series of elderly Caucasian women with long-standing actinic damage, pruritus and prurigo nodules who subsequently developed keratoacanthomas.
Were any of the findings unexpected?
Dr. Stein: This was the first time this overlap of sun damage, itch and concurrent keratoacanthomas has been described. Based on conversations with other dermatologists, this type of patient many not be that uncommon, but can be very challenging to treat.
DermatologistsBlog.com: What should clinicians and patients take away from this study?
Dr. Stein: Age and sun-related changes in the skin may be associated with the formation of keratoacanthomas. When treating these patients, consider using low-dose systemic retinoids, such as acitretin. Cyclosporine can also be useful, but needs to be used with caution because of its increased risk for skin cancers.
DermatologistsBlog.com: What recommendations do you have for future research as a result of your study?
Dr. Stein: Our study highlights the relationship between actinic damage, the immune system and keratoacanthoma development. Further research into the biological basis of this condition would be helpful to better elucidate this relationship and to develop better treatment options.
Keratoacanthomas arising in association with prurigo nodules in pruritic, actinically damaged skin
Timothy P. Wu, Kristen Miller, David E. Cohen, Jennifer A. Stein
Journal of the American Academy of Dermatology – 13 May 2013 (10.1016/j.jaad.2013.03.035)