DermatologistsBlog.com Interview with
Byungwoo Ryu, PhD.
Assistant Professor of Dermatology
Director of Biomarker Research Program
Boston University School of Medicine
609 Albany Street, J-502
Boston, MA 02118
DermatologistsBlog: What are the main findings of the study?
Dr. Ryu: We performed a retrospective correlation study of Neuropilin-2 (NRP2) expression with malignant progression using small cohorts of FFPE melanoma tissue samples in order to evaluate potential value of the NRP2 as a prognostic marker for cutaneous melanoma. We used a unique qRT-PCR assay technique that we developed for the quantitative measurement of gene expression in the FFPE tissue specimens and we found that:
1) NRP2 expression levels are positively correlated with disease progression;
2) There is a positive correlation between NRP2 expression and Breslow depth in a group of primary melanoma tissue samples.
These findings suggest NRP2 may be a useful biomarker for malignant progression of melanoma and may be a useful tool for the early identification of melanoma patients at high risk of metastasis.
Read the full post »